The CRISPR/Cas9 system includes the Cas9 nuclease, which can be programmed to target and cleave specific sequences in the genome through the use of a guide RNA (gRNA) that directs it to any user specified position in the genome. The Cas9 protein binds to the site specified by the gRNA and produces a targeted double-strand break in the DNA.

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Genome Engineering Technology

Genome engineering is a rapidly evolving field that enables the facile manipulation of complex genomes. Genome engineering uses custom endonucleases to create targeted DNA double-strand breaks in genomic DNA. The repair of these DNA breaks can lead to loss-of-function mutations or can be harnessed to create targeted, user-defined genomic modifications.

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About Us


The Genome Engineering and IPSC Center (GEiC)

The Genome Engineering and IPSC Center (GEiC) was formed by the consolidation of two pre-existing cores, the Genome Engineering Center and the Induced Pluripotent Stem cell (iPSC) core, both established by the Department of Genetics in the past few years. These two Centers were established to facilitate functional genomic studies through the use of patient-derived iPSCs and the generation of modified cells and organisms using genome editing technologies.

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